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Animal Use on the UIUC Campus | |
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| ORGANISM |
HOST |
ADVERSE EFFECTS |
| *Mouse Hepatitis Virus (MHV) |
mouse |
immunosuppression, increased susceptibility to other infections and experimental agents, unexplained deaths |
| *Sendai Virus |
mouse, rat, hamster |
immunosuppression, neonatal and adult deaths, decreased fertility |
| *Ectromelia (mouse pox) |
mouse |
subclinical infection to high mortality depending on mouse age, genotype and virus strain |
| *Lymphocytic Choriomeningitis Virus (LCMV) |
mouse, rat, hamster |
immunosuppression, mortality, potential zoonotic agent |
| *Mouse Encephalomyelitis Virus (MEV, TMEV, GD8) |
mouse, rat |
subclinical inflection; neuropathogneic |
| *Polyoma Virus |
mouse |
chronic wasting and paralysis, common contaminant of tumors and other cell lines |
| *Pneumonia Virus of Mice (PVM) |
mouse, rat, hamster |
subclinical respiratory infection; wasting disease in immunocompromised rodents |
| *Orphan Parvovirus (OPV) |
mouse, rat |
immunomodulation, cytolytic to lymphoid cells |
| Minute Virus of Mice (MVM) |
mouse |
immunomodulation |
| Toolan's and Kilham's Rat Virus (H-1, KRV) |
rat |
immunosuppression, hepatotoxicity, congenital musculoskeletal defects |
| *Rat Coronavirus (RCV) |
rat |
decreased fertility, respiratory compromise |
| Lactate Dehydrogenase Elevating Virus (LDV) |
mouse |
common tumor contaminant, suppresses antibody production and cell-mediated immunity |
| Murine Cytomegalovirus (MCMV) |
mouse |
immunomodulation; clinical disease in infant or immunosuppressed mice |
| *Mouse Adenovirus (MAD) |
mouse |
kidney, adrenal lesions; runting and mortality in suckling mice |
| *Rotavirus ((EDIM) |
mouse |
diarrhea, increased neonatal mortality, immunomodulation |
| *Reovirus |
mouse, rat, hamster |
common tumor contaminant |
| K virus |
mouse |
common tumor contaminant, increases severity of other infections |
| *Hantaan virus |
mouse, rat |
subclinical disease; potential zoonotic agent |
| *Mycoplasma pulmonis |
mouse, rat |
chronic respiratory disease resulting in morbidity and mortality |
| *Clostridium pilliforme (Tyzzer's Disease) |
mouse, rat, hamster |
subclinical infection to high mortality |
| *Cilia-Associated Respiratory Bacillus (CAR Bacillus) |
mouse, rat |
subclinical respiratory disease |
| *Encephalitozoon cuniculi |
mouse, rat, hamster |
common tumor contaminant, brain and kidney lesions |
| pinworms (Syphacia spp, Aspicularis spp) |
mouse, rat |
usually subclinical; immunomodulation; |
| fur mites (Myobia musculi, Radfordia affinis, Myocoptes musculinus, Psorergates simplex, Polyplax spinulosa, Radfordia ensifera, Ornithonyssus bacoti) |
mouse, rat |
infertility, immunomodulation, decreased life span |
# This appendix is not all-inclusive for rodent pathogens; however, diseases listed have been documented to interfere with research results, or represent potential human health hazards.
* Denotes disease tested for on a
comprehensive serologic profile obtained from University of Missouri.
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